Metabolic Psychiatry
Focusing on the mind-body connection
The Cellular Foundation of Mental Health
Mental health is inextricably linked to the metabolic health of the body. The brain is the most energy-demanding organ in the human body, consuming roughly 20% of your total energy. When metabolic pathways—the systems that convert nutrients into cellular fuel—become dysregulated, it often manifests as psychiatric symptoms: brain fog, treatment-resistant depression, cognitive decline, and chronic anxiety.
A Molecular Perspective on Brain Energy
In our practice, we view psychiatric symptoms as potential signals of "neuro-metabolic" dysfunction. Leveraging my background in neurobiological research and genomics, we go beyond surface-level symptom management. We investigate the biological root causes, looking at biomarkers of inflammation, insulin resistance, and mitochondrial health to understand why your brain may be struggling to maintain its energy balance.
Our Neuro-Metabolic Approach
We utilize specialized laboratory testing and clinical data to develop an individualized metabolic roadmap. This includes:
Biomarker Analysis: Assessing systemic inflammation (CRP), metabolic hormones, and nutritional co-factors that act as "fuel" for neurotransmitter synthesis.
Mitochondrial Support: Implementing precision psychopharmacology and targeted nutraceuticals designed to optimize cellular energy production.
The Gut-Brain Axis: Addressing the metabolic relationship between the microbiome and neuro-inflammation.
Insulin Signaling & Brain Health: Evaluating how glucose regulation impacts mood stability and cognitive clarity.
Clinical Research & Selected Publications
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging. Nature Aging, 2023 > The Insight: This study identifies the genetic drivers of biological aging. In our metabolic practice, we use these insights to target the pathways that keep the brain "young" and metabolically resilient, focusing on long-term neuro-longevity.
Multi-omic underpinnings of epigenetic aging and human longevity. Nature Communications, 2023 > The Insight: By analyzing the "epigenetic clock"—the chemical markers on your DNA that track biological age—this research explores why some individuals age more successfully than others. It provides the molecular basis for our precision approach to longevity and "healthspan."
Global and tissue-specific transcriptomic dysregulation in human aging: Pathways and predictive biomarkers. Geroscience, 2025 > The Insight: By identifying molecular biomarkers of aging across different body tissues, this work allows us to move toward "Predictive Psychiatry." We look at transcriptomic data to understand how your specific biological aging process might be affecting your mood and cognitive clarity.
Targeting Oxidative Stress in Neurodegenerative Disorders: A Novel Role for PCSK9 Inhibition? ACS Chemical Neuroscience, 2024 > The Insight: This research explores how cholesterol-regulating pathways (PCSK9) may protect the brain from oxidative stress. It underpins our "Neuro-Longevity" pillar, where we focus on protecting the brain from the cellular damage that leads to cognitive decline and treatment resistance.